Vesicular stomatitis virus (VSV) is a prototypic non-segmented, negative-strand RNA virus in the genus of Vesiculovirus of the family Rhabdoviridae. The VSV genome is comprised of approximately 11,000 nucleotides which encodes five major viral proteins including G protein (G), large protein (L), phosphoprotein (P), matrix protein (M) and nucleoprotein (N).