The significant genomic regulatory function that non-coding regions play in gene transcriptional activity has been made evident by developments in high-throughput sequencing methods. A data integration bioinformatics method called the Transcriptome-Wide Association Study (TWAS) was created in 2005 with the goal of identifying genes that produce complex features as a result of gene-regulated transcriptional activity. To find gene-trait correlations from GWAS datasets, TWAS use expression prediction models from genotypes trained on expression reference panels, such as eQTL (expression quantitative trait loc) cohorts containing expression and genotype data.
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