It is a rare, chronic autoimmune disease. In such a condition, normal tissues are replaced with thick, fibrous and dense tissues. Quite normally, your immune systems defend your body against and infection or disease. However the sufferers of Scleroderma, their immune system actually trigger some other cells in order to produce a large amount of collage. (it’s a protein). Such extra collagen is then deposited in your organs and skin, causing thickening and hardening.