Non-Invasive Liver Fibrosis Tests Indeed, liver fibrosis refers to the formation of scar tissue in the liver which in turn hinders the structure and functioning of the organ. As it develops, the forms of fibrotic disease caused by excessive scarring of the liver may progress to cirrhosis, liver incapacitation, and stage a potential threat of liver cancer. Even without more serious underlying conditions, the diagnosis and subsequent evaluation of liver fibrotic changes is extremely important since many viral infections, such as hepatitis, and alcohol-, as well as non-alcohol-based, fatty liver disease are prevalent in the population.