When it comes to navigating the use of Hydroxyurea Dose for Polycythemia Vera, it is important to understand potential side effects and complications. Common side effects include nausea, vomiting, diarrhea or constipation, headache, fatigue, and skin reactions. Rare but serious side effects can also occur such as liver injury or bone marrow suppression. It is important to discuss all potential risks with your doctor before starting treatment with hydroxyurea.