The cerebellum plays an important role in maintaining balance and movement coordination. Some studies showed that the functional defects of different cerebellar neurons may result in cerebellar dysfunction. In the past decades, postmortem tissues are major source for research of disease-related neuronal phenotypes. Subsequently, immortalized cell lines, as well as rodent animal models, have been used in neurodegenerative diseases study. In recent years, human induced pluripotent stem cells (iPSCs) present great potentials for disease modeling, the cerebral organoids generated from patients’ iPSCs are beneficial for the proposal of treatment strategies. For more information: Cerebellar Organoids
