Fibroblast Growth Factor (FGF) is a class of cell growth factors. 23 members of the FGF family have a wide range of mitogenic and cell survival activities and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. Aberrant activation of the signaling pathway is associated with the onset and progression of many diseases, including cancer, diabetes, and cardiovascular disease. Therefore, FGF and its receptors may become new targets for the treatment of these diseases.