Does an ozone machine kill mold? Yes, ozone machines can help eliminate mold by releasing O₃ gas that breaks down mold spores and bacteria through oxidation. This can reduce mold growth and eliminate musty odors. However, ozone treatment has limitations—while it can kill surface mold and airborne spores, it doesn’t address mold deep within materials or resolve the underlying moisture problem. Additionally, high ozone concentrations can be harmful to humans, pets, and plants, so it’s important to only use ozone machines in unoccupied spaces and ventilate the area afterward. For long-term results, ozone should be combined with proper mold remediation, including fixing water leaks and thorough cleaning. Ozone is a helpful tool but not a permanent fix!