Covalent Organic Frameworks (COFs) have gained considerable attention in the field of drug delivery due to their unique properties and tunable structures. As highly porous and crystalline materials, COFs offer a platform for efficient drug encapsulation and controlled release. Their tailored pore sizes and surface functionalities enable selective interactions with drugs, enhancing loading capacities and preventing premature release. COFs can protect drugs from degradation in the physiological environment, improving drug stability and bioavailability.