Cialis blood pressure can cause a mild drop in blood pressure due to its vasodilation effects, which may be more noticeable in people with existing blood pressure issues. In general, Cialis is safe for most people, but if you have hypertension or are taking medications for blood pressure, it is important to consult with your healthcare provider. Cialis should not be used with nitrates or alpha-blockers without medical supervision due to the risk of severe hypotension. Alcohol can enhance the blood pressure-lowering effects of Cialis, increasing the risk of dizziness or fainting. It’s advisable to limit alcohol consumption when taking the medication.