Embarking on an exploration of the essential aspects surrounding Annual Product Quality Review (APQR), this investigation delves into the fundamental questions of What, Why, and Where. As a cornerstone of quality management within regulated industries, it holds significant importance in assessing product quality standards and manufacturing processes. By dissecting these key components, this exploration aims to provide a comprehensive understanding of its purpose, significance, and application across various sectors. Let’s delve deeper into the 3 W’s of APQR to unravel its intricacies and unveil its impact on ensuring quality, compliance, and continuous improvement within regulated environments.