Numerous studies examined the role of the microbiome in the onset of different pathologies, with most of them focusing on the intestinal microbiome.Recent studies have shown that alterations in the blood microbiota signature are associated with chronic inflammatory diseases, such as Diabetes, Obesity, and Cardiovascular diseases.This article briefly discussed blood microbiota profiles and cardiovascular disease.
Cardiovascular diseases (CVDs) are now the leading cause of morbidity and mortality worldwide (Khan et al., 2022). Despite substantial breakthroughs in prevention, fast detection, and treatment, CVDs continue to place a significant socioeconomic burden on health systems and communities. CVDs prevalence has risen by 93%, and mortality has risen by 54%, accounting for more than a third of all annual deaths globally (Roth et al., 2021). While non-communicable diseases account for 60% of disability-adjusted life-years worldwide. CVD accounts for roughly a quarter of this burden (Gheorghe et al., 2018). In addition to conventional risk factors, the role of recent changes in blood microbial mix in the progression of cardiovascular disease has gotten a lot of attention.
As human blood used to be considered a sterile environment composed of plasma, blood cells, and platelets, the presence of bacteria was considered a sign of infection (Katz, 1981). In the last two decades, multiple studies targeting the 16S ribosomal RNA gene have revealed the existence of a dominant phylum of blood-borne bacteria, which includes Proteobacteria, Actinobacteria, Firmicutes, and Bacteroidetes (McLaughlin et al., 2002; Amar et al., 2011, 2013; Dinakaran et al., 2014; Païssé et al., 2016; Gosiewski and Huminska, 2017; Loohuis et al., 2018; Qiu et al., 2019). Figure 1 shows that longer-term human blood microbiome constancy is indicated. In contrast, the microbiota structure in the blood rarely stays the same.
It has become increasingly popular to analyze the human microbiome because of the promise of gaining a greater understanding of biological systems. There has been previous work attempting to establish an evolutionary relationship between oral and gut bacteria; this study focuses on our blood microbial community. Developing a comprehensive understanding of the blood microbiome will undoubtedly lead to breakthroughs in how we treat diseases originating in the blood. “In addition to the therapeutic potential of tissue-specific microbiomes, this kind of analysis is highly sought after”. What is the significance of investigating the microbiome of the blood?. “Blood microbiomes research has important implications for environmental and medicinal microbiology. The environment is inextricably linked to our understanding of human microbiology and its surrounding bacteria”.Microbiology research includes not only the diagnosis, prognosis, and therapy of diseases but also the study of beneficial bacteria. As a result, microbiome analysis combats the prevention and treatment of numerous diseases.
Explore more: https://www.pharmafocusasia.com/articles/analysis-of-blood-microbiota-compositionin-cardiovascular-disease-patients
