The liver is the biggest and heaviest internal organ in the body. It is essential for the synthesis of blood plasma proteins, immunological components, cholesterol, and other body materials. Bile is also produced, which facilitates the digestion of fat. In adults, the liver weighs a little over three pounds. This page will discuss the typical liver size in mm, inches, and cm for both males and females according to age, as well as the diseases that can result in abnormal liver size.